Publications

Found 17 results
2014
Singh V, Peng CSam, Li D, Mitra K, Silvestre KJ, Tokmakoff A, Essigmann JM.  2014.  Direct observation of multiple tautomers of oxythiamine and their recognition by the thiamine pyrophosphate riboswitch.. ACS Chem Biol. 9(1):227-36.
Li D, Fedeles BI, Singh V, Peng CSam, Silvestre KJ, Simi AK, Simpson JH, Tokmakoff A, Essigmann JM.  2014.  Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine.. Proc Natl Acad Sci U S A. 111(32):E3252-9.
2011
Hiller DA, Singh V, Zhong M, Strobel SA.  2011.  A two-step chemical mechanism for ribosome-catalysed peptide bond formation.. Nature. 476(7359):236-9.
2010
Hiller DA, Zhong M, Singh V, Strobel SA.  2010.  Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects.. Biochemistry. 49(18):3868-78.
2007
Gutierrez JA, Luo M, Singh V, Li L, Brown RL, Norris GE, Evans GB, Furneaux RH, Tyler PC, Painter GF et al..  2007.  Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.. ACS Chem Biol. 2(11):725-34.
Singh V, Schramm VL.  2007.  Transition-state analysis of S. pneumoniae 5'-methylthioadenosine nucleosidase.. J Am Chem Soc. 129(10):2783-95.
Singh V, Luo M, Brown RL, Norris GE, Schramm VL.  2007.  Transition-state structure of neisseria meningitides 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.. J Am Chem Soc. 129(45):13831-3.
Luo M, Singh V, Taylor EA, Schramm VL.  2007.  Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases.. J Am Chem Soc. 129(25):8008-17.
2006
Singh V, Shi W, Almo SC, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Mee S, Zheng R et al..  2006.  Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.. Biochemistry. 45(43):12929-41.
Singh V, Schramm VL.  2006.  Transition-state structure of human 5'-methylthioadenosine phosphorylase.. J Am Chem Soc. 128(45):14691-6.
2005
Singh V, Evans GB, Lenz DH, Mason JM, Clinch K, Mee S, Painter GF, Tyler PC, Furneaux RH, Lee JE et al..  2005.  Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli.. J Biol Chem. 280(18):18265-73.
Evans GB, Furneaux RH, Lenz DH, Painter GF, Schramm VL, Singh V, Tyler PC.  2005.  Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.. J Med Chem. 48(14):4679-89.
Lee JE, Singh V, Evans GB, Tyler PC, Furneaux RH, Cornell KA, Riscoe MK, Schramm VL, P Howell L.  2005.  Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.. J Biol Chem. 280(18):18274-82.
Ting L-M, Shi W, Lewandowicz A, Singh V, Mwakingwe A, Birck MR, Ringia EATaylor, Bench G, Madrid DC, Tyler PC et al..  2005.  Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins.. J Biol Chem. 280(10):9547-54.
Singh V, Lee JE, Núñez S, P Howell L, Schramm VL.  2005.  Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues.. Biochemistry. 44(35):11647-59.
2004
Singh V, Shi W, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL.  2004.  Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.. Biochemistry. 43(1):9-18.
Evans GB, Furneaux RH, Schramm VL, Singh V, Tyler PC.  2004.  Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase.. J Med Chem. 47(12):3275-81.